Magnesium for Anxiety and Depression? The Science Says Yes!

Magnesium is considered one of the essential minerals that is involved in more than 300 different body processes, including keeping your heart beating and maintaining electrical stability of your nervous system. Magnesium is used by the body to help regulate serotonin and other neurotransmitters. And some researchers believe that low Magnesium is the problem behind treatment resistant depression. In this video I explain how Magnesium works for depression and anxiety.

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Serefko, A., Szopa, A., Wlaź, P., Nowak, G., Radziwoń-Zaleska, M., Skalski, M., & Poleszak, E. (2013). Magnesium in depression. Pharmacological reports : PR, 65(3), 547–554.

Murck H. (2013). Ketamine, magnesium and major depression–from pharmacology to pathophysiology and back. Journal of psychiatric research, 47(7), 955–965.

Gendle, M. H., & O’Hara, K. P. (2015). Oral magnesium supplementation and test anxiety in University undergraduates. Journal of Articles in Support of the Null Hypothesis, 11(2), 21+.

Want to know more about mental health and self-improvement? On this channel I discuss topics such as bipolar disorder, major depression, anxiety disorders, attention deficit disorder (ADHD), relationships and personal development/self-improvement. I upload weekly. If you don’t want to miss a video, click here to subscribe.

Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.


  1. My pharmacist always told me to take magnesium. Thank you doctor you've confirmed it and I'm starting it asap.

  2. Soooo, the magnesium totally works, however being so keen to try it out, I bought the wrong one. The side-effects of the Magnesium hydroxide have been horrendous to say the least… 😳

  3. I have been taking magnesium citrate for over a year it has done nothing for anxiety or the so-called calming effect but it works well as a laxative. So this theory is bogus.

  4. Just curious if anyone is reading this now, Saturday Jan 15th, when is it best to take the magnesium. People always comments but never mention this… Dr. Marks, if you are reading this, what do you suggest. I'm going to take it at night unless you suggest otherwise. Just want to stop shaking… and go back to work….rent is due soon!

  5. I take magnesium and Vitamin D 10000 IU that includes Vitamin K (K-1, K-2 MK-4 and K-2 MK-7) daily and I feel great!

  6. I am a psychiatry resident in a European country. Dr. Marks is fabulous. Although we residents have textbooks, I still listen to her because it sticks in my brain, everything she says. Besides I find her hot! 😉

  7. Dr. Marks, you're amazing! …providing accurate information that so many seek without being able to find from many other so-called professionals. Bless you!

  8. I've been battling anxiety for the last 4 months. It appeared out of nowhere. Perhaps I may be low on magnesium. I also have alot of body twitches. Does anyone know what causes this?

  9. Hi, do you (or anyone in the comments) have access to studies on how vitamin deficiency affects gene expression? Will be doing my own research, but figured there's a good chance someone here can link something interesting- thanks

  10. can anyone help in guiding me in what brand of magnesium supplements works best and is absorbed easily? I heard of the brand pure but have read some mixed reviews ever since they were bought out by nestle. It would be a huge help.

  11. Thank you for sharing this Dr. Marks! You did a great summary of all the mechanisms. I also love suggesting magnesium threonate for my clients with history of any brain trauma. Keep up the great work!

  12. Speaking about magnezium being important in treatment resistant depression, there are plenty of people who like to use psycho-active substances and they have learned that magnesium in your body strongly affects how well the substances affect the users, so drug addicts chasing the high have been onto this for some time.

  13. I really appreciate the time and passion you put into these videos. I love to learn and you are an excellent educator. Keep up the great work! Thank you!!

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