Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine)



COVID-19 Update 69 with Roger Seheult, MD of
N-Acetylcysteine (NAC) is an over the counter supplement that has been utilized by clinicians for years to treat acetaminophen (Tylenol) overdose, as a mucolytic, and for other medical problems. There is compelling research that NAC may also reduce the severity of viral infections like influenza, and perhaps reduce the risk of blood clots (thromboembolism) as well. Could NAC be effective in COVID-19? Dr. Seheult illustrates these ideas and discusses the peer-reviewed data involved.

Links referenced in this video:

Johns Hopkins Tracker –

Taylor & Francis –

European Respiratory Journal –

Biochemical Pharmacology –

Free Radical Research –

Experimental and Therapeutic Medicine –

Medicine –

Journal of Medical Toxicology –

Blood Coagulation & Fibrinolysis –

Redox Biology –

Circulation –

Blood Advances –

Journal of Clinical Investigation 1 –

Journal of Clinical Investigation 2 –

CEBM –

Clinical Trials –

Some previous videos from this series (visit MedCram.com for the full series):
– Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
– Coronavirus Pandemic Update 67: COVID-19 Blood Clots – Race, Blood Types, & Von Willebrand Factor
– Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19
– Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors)
– Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update
– Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)?
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? This video was removed by YouTube
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID 19 (V/Q vs Shunt vs Diffusion)
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses?
– Coronavirus Outbreak / Pandemic Update 55: How COVID 19 Infection Attacks The Immune System & Differs From HIV:
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

All coronavirus updates are at MedCram.com, and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

Media Contact: customers@medcram.com
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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus

49 comments

  1. You can help support our frequent COVID-19 updates by subscribing to this channel and visiting us at https://www.MedCram.com for clear and concise explanations of over 60 medical topics.
    We also offer CMEs for medical professionals, and group rates for medical programs and institutions.
    All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic:
    – Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19: https://youtu.be/Ja-jhcXMGj0
    – Coronavirus Pandemic Update 67: COVID-19 Blood Clots – Race, Blood Types, & Von Willebrand Factor: https://youtu.be/JOlVkES_kC8
    – Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19: https://youtu.be/OudhmwulJHY
    – Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors): https://youtu.be/gzx8LH4Fjic
    – Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update: https://youtu.be/Z2hfGcTokiY
    – Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
    – Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
    – Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: https://youtu.be/22Bn8jsGI54
    – Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
    – Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): https://youtu.be/NM2A2xNLWR4
    – Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): https://youtu.be/nO4xgcIaPeA
    – Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
    – Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
    – Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
    – Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? https://youtu.be/kgzFAdYwYLM
    – Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? https://youtu.be/o8aG63yigjA
    – Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
    – Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
    – Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
    – Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
    – Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
    – Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: https://youtu.be/H1LHgyfPPQ8
    – Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: https://youtu.be/EFRwnhfWXxo
    – Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: https://youtu.be/G1zsE9_85i4
    – Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? https://youtu.be/A4eu-h_owaI
    – Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? https://youtu.be/LqKwAIIy-Mo
    – Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? https://youtu.be/q4P91VrfPGw
    – Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: https://youtu.be/hPz5KxgI_K4
    – Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: https://youtu.be/dT6mHi_8V5E
    – Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: https://youtu.be/AToF8O5T86s
    – Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: https://youtu.be/MoisrCTu0SY
    – Coronavirus Pandemic Update 37: The ACE-2 Receptor – The Doorway to COVID-19 (ACE Inhibitors & ARBs): https://youtu.be/1vZDVbqRhyM
    – Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: https://youtu.be/vww1nIIoqmw
    – Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: https://youtu.be/vE4_LsftNKM
    – Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: https://youtu.be/U7F1cnWup9M
    – Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74
    – Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U
    – Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk
    – Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: https://youtu.be/gmqgGwT6bw0
    – Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: https://youtu.be/XjEacUyp4vY
    – Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: https://youtu.be/quDYb_x54DM
    – Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: https://youtu.be/xQwfuJgJ9lo
    – Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? https://youtu.be/bV1CZxJ-uvU
    – Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends: https://youtu.be/UImSVhLLeGY
    – Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: https://youtu.be/wFoj2L2LpNA
    – Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: https://youtu.be/JGhwAGiAnJo
    – Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: https://youtu.be/OqpHvK0XADY
    – Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: https://youtu.be/9BYaywITXYk
    – Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: https://youtu.be/Ka48UZDDzLY
    – Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: https://youtu.be/4HK9QEy1KJ8
    – Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: https://youtu.be/vE4pBkslqS4
    – Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): https://youtu.be/wlbM6VVkVZM
    – Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): https://youtu.be/qqZYEgREuZ8
    – Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): https://youtu.be/o804wu5h_ms
    – Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: https://youtu.be/pDnmHu8x9C4
    – Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: https://youtu.be/0UgrPgJdzp0
    – Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: https://youtu.be/GT3_A1bf9pU
    – Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): https://youtu.be/pfGpdFNHoqQ
    – Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): https://youtu.be/gPwfiQgGsFo
    – Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: https://youtu.be/8Hjy3UfaTSc
    – Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: https://youtu.be/GpbUoLvpdCo
    – Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: https://youtu.be/nW3xqcGidpQ
    – Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: https://youtu.be/UGxgNebx1pg
    – Coronavirus Update 5: Mortality Rate vs SARS / Influenza: https://youtu.be/MN9-UXsvPBY
    – How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
    – Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: https://youtu.be/SJBYwUtB83o
    – Coronavirus Symptoms, Diagnosis, Treatment: https://youtu.be/UCG3xqtcL3c
    – Coronavirus Outbreak – Transmission & Updates: https://youtu.be/9vMXSkKLg2I

  2. I started taking NAC tablets 3 days ago , already my back pain is about 50% better.
    Anybody know why it could help my lower back pain?

  3. Can the body produce its own NAC? I’m thinking so. I’ve had chronic lymph swelling and take a combination of Chinese herbs to fix it. Should I buy NAC, or continue my herbs? This is the question for me.

  4. What an incredible analysis of NAC!! Is there any other useful supplementation post covid 19 infection to help mitigate damage to the inner ear hearing cells?

  5. Good video…I've been getting mine at lowcarbcabana but I was more interested in the way it fights free radicals originally..then covid came along…appreciate the amount of work you invested in making and sharing the research doc! I hope you add a section on longevity to medcram in the future as well.

  6. mom was discharged from hospital last week, severe covid. her room air o2 sat was only 88% supine, 93% prone, so she's on o2 support 24/7 at home. her doc gave her dextromethorphan cough syrup, didn't help her very productive cough, so she refused to take more of it after the first bottle. switched her to NAC and Symbicort (by advice from my pulmonologist colleague) plus several other supplements, her sat went up to 95% supine with room air in just 3 days.

  7. And now 2021 NAC is being considered a drug. So the FDA has taken it off the open market so they can use it and make money off of it.

  8. Thank you very much. This is the only video or article that gives a good overview of the real findings about NAC. I'm going to share this with my friends and hope they'll start taking it too!

  9. I thought antibiotics were for bacterial and not viruses. The reason I ask is there are dr’s saying the combine antibiotics with N A C.

  10. I’ve used NAC for 7 years, it’s awesome. Important note, anyone w chronic issues or lifestyle stresses (lack of sleep drinking smoking taking any medication regularly etc) needs a lot more than the ideal subjects NaC has been successfully tested on.600mg daily worked for them, but anyone w asthma allergies sinus infections fibromyalgia Lyme etc arthritis usually needs at least 1200mg 2-3 times a day, & more usually works better.

  11. I’m trying to understand,
    Are you saying that SOD is bad? And Glutathione is bad? These supplements are they bad? Or Good to take?

  12. So now NAC is being reclassified as a drug now that we see evidence of its efficacy against COVID. This is an obvious attempt to ensure the only course of action is the vaccines and to quiet the fact that it has been known that this was an effective treatment and was ignored in order to push the vaccines. People died and this needs to be investigated.

  13. Hi, may I know the followings?
    1) Can a healthy person can take NAC?
    2) Can NAC be taken everyday?
    3) Is a break required? And if so, how many days can a healthy person take NAC for before the break and how many days break is required?
    4) Can NAC be taken pre-Covid-19 symptom? Or can it only be taken after symptoms appear?
    5) There are many NAC available on the shelf. Which dosage a day is recommended? 600mg, 1000mg? I do not want to ask my physician because he would compel me to take the vaxx!
    6) Can kids between 10 and 15 take NAC? Again I won't ask my physician because I know what they will say!
    I look forward to your reply soon!
    Thank you!

  14. Recently banned why? Why? I use this for asthma and now its gone!!!! Was my lifesaver, now you know big pharma has other interests

  15. Is NAC an anti inflammatory as well? Can NAC reduce Long inflammation caused by co vid 19? Doctors from Argentina and el Salvador use Ibuprofen to eliminate long inflammation caused by co vid. Which one is a better anti inflammatory?

  16. Love seeing more and more on the benefits of NAC. Even with the 'anti-antioxidant' medical groups claiming harm of any anti oxidant.

    Now, only issue if finding a reputable company selling the true stuff, outside of food, that we can trust!

  17. Hi…Are there any issues or known side effects taking a NAC supplement if you are an Asthma and Diabetic sufferer? From your video it seems not….just double checking.

  18. There are some studies showing NAC to cause tumors in the lungs in mice meaning some real cancer tumors so it is still very risky even though it seems great it has potential risk so is better not to use longterm.

  19. I can’t say whether NAC has been helpful for me. I will however say the capsules I have are gross and smell like rotten eggs.

  20. Studies indicated that COVID-19 patients experienced gastrointestinal symptoms such as diarrhea (24.2%), anorexia (17.9%), and nausea (17.9%). Hence, coronavirus infections are known to cause diabetes and severe inflammation.

    When the body is unable to use glucose, difficulty breathing, rapid breathing, or shortness of breath may result. Note that insulin resistance is when cells in your muscles, fat, and liver don't respond well to insulin and can't use glucose from your blood for energy. One major warning sign to watch out for is shortness of breath. This symptom arises when blood sugar levels cause toxic acids to build up in your blood and urine.

    Although NAC is a powerful antioxidant that increases glutathione, an in vivo human study showed an increase of glucose consumption under N-acetyl cysteine (NAC) administration, that is, an improvement of insulin sensitivity.
    So you could keep taking NAC for ages and be having a sluggish-like cure because it only "somewhat" assists in insulin sensitivity. Once u stop NAC, ur symptoms come back.

    Moreover, we are told to take Cinnamon, turmeric for COVID 19. Note that they both increase insulin sensitivity.

    SOLUTION: Check with your doctor for possible insulin sensitivity medication or consume an "alpha-lipoic acid" supplement, which is known to increase insulin sensitivity.

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